Abstract
Ether à go-go (EAG) K(+) channels have been shown to be involved in tumor generation and malignant growth. Gliomas have not been investigated thus far. Using RT-PCR we investigated healthy human brain and human gliomas of different subtypes and malignancy grades for the expression of human EAG1 and eag-related gene (ERG) 1 channels. mRNA of both channels was detected in all tissues. Expression was strong in normal brain, moderate in high-grade and high in low-grade gliomas. Our findings suggest a differential expression of hEAG1 and hERG1 in gliomas depending on the malignancy grade and nature of the tumor cells. However, the hypothesis that EAG channels are related to the oncogenic process itself is only partly supported by this study.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Astrocytoma / genetics
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Astrocytoma / metabolism
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Astrocytoma / pathology
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Brain / metabolism*
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Brain / pathology
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ERG1 Potassium Channel
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Ether-A-Go-Go Potassium Channels
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Gene Expression Regulation, Neoplastic / physiology*
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Glioblastoma / genetics
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Glioblastoma / metabolism
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Glioblastoma / pathology
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Glioma / genetics
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Glioma / metabolism*
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Glioma / pathology
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Humans
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Oligodendroglioma / genetics
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Oligodendroglioma / metabolism
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Oligodendroglioma / pathology
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Potassium Channels, Voltage-Gated / biosynthesis*
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Potassium Channels, Voltage-Gated / genetics
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RNA, Messenger / biosynthesis
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RNA, Messenger / genetics
Substances
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ERG1 Potassium Channel
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Ether-A-Go-Go Potassium Channels
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KCNH2 protein, human
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Potassium Channels, Voltage-Gated
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RNA, Messenger