Abstract
Hepatitis C virus (HCV) quasispeciation was studied in two children vertically coinfected with HCV and human immunodeficiency virus type 1 (HIV-1). HCV quasispecies diversification and liver injury were more significant in patient C1, who was immunocompetent with anti-HIV therapy, than in patient C2, who was immunosuppressed, in consistency with modulation of HCV quasispeciation and liver injury by immunocompetence in coinfected children.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Acquired Immunodeficiency Syndrome / complications
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Acquired Immunodeficiency Syndrome / drug therapy
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Acquired Immunodeficiency Syndrome / pathology*
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Acquired Immunodeficiency Syndrome / transmission
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Antiretroviral Therapy, Highly Active
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Child
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Disease Progression
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Female
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Hepacivirus / classification*
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Hepatitis C / complications
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Hepatitis C / pathology*
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Hepatitis C / transmission
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Humans
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Infant
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Infectious Disease Transmission, Vertical*
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Liver / pathology
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Male
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Molecular Sequence Data
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Phylogeny
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Pregnancy
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Pregnancy Complications, Infectious / virology
Associated data
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GENBANK/AY385797
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GENBANK/AY386123