Molecular evidence for absence of Y-linkage of the Hairy Ears trait

Eur J Hum Genet. 2004 Dec;12(12):1077-9. doi: 10.1038/sj.ejhg.5201271.

Abstract

The human Hairy Ears phenotype has traditionally been regarded as the only Y-linked heritable trait. Here, we use Y-chromosomal DNA binary-marker haplotyping to show that a cohort of southern Indian Hairy-Eared males carries Y chromosomes from many haplogroups of the Y-phylogeny, which, under a hypothesis of Y linkage, would require multiple independent mutations within a single population. We further show that there is no significant difference between the Y-haplogroup spectrum in Hairy-Eared males and that in a geographically matched control sample of unaffected males. The trait cannot, therefore, be Y-linked in southern Indians, and by extension, is unlikely to be so in any population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosomes, Human, Y*
  • Ear, External / abnormalities*
  • Genetic Markers
  • Hair / abnormalities*
  • Haplotypes
  • Humans
  • Male

Substances

  • Genetic Markers