A new approach to bioconjugates for proteins and peptides ("pegylation") utilising living radical polymerisation

François Lecolley; Lei Tao; Giuseppe Mantovani; Ian Durkin; Sylvie Lautru; David M Haddleton

doi:10.1039/b407712a

A new approach to bioconjugates for proteins and peptides ("pegylation") utilising living radical polymerisation

Chem Commun (Camb). 2004 Sep 21:(18):2026-7. doi: 10.1039/b407712a. Epub 2004 Jul 28.

Authors

François Lecolley¹, Lei Tao, Giuseppe Mantovani, Ian Durkin, Sylvie Lautru, David M Haddleton

Affiliation

¹ Department of Chemistry, University of Warwick, Coventry, UKCV4 7AL.

PMID: 15367957
DOI: 10.1039/b407712a

Abstract

The synthesis of protein-polymer bioconjugates is reported using N-succinimidyl ester functionalised polymers from transition metal mediated living radical polymerisation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acrylates / chemistry*
Buffers
Hydrogen-Ion Concentration
Hydrolysis
Kinetics
Methacrylates
Peptides / chemistry
Polyethylene Glycols / chemistry*
Proteins / chemistry*
Succinimides / chemistry*

Substances

Acrylates
Buffers
Methacrylates
Peptides
Proteins
Succinimides
poly(ethylene glycol)-dimethacrylate
Polyethylene Glycols