Objectives: To evaluate alternative equations for the estimation of low-density lipoprotein cholesterol (LDL-C) than the Friedewald equation in hemodialysis patients.
Design and methods: The equations LDL-C = 0.41TC - 0.14TG + 0.66ApoB - 10.43 and LDL-C = 0.94TC - 0.94HDL-C - 0.19TG were evaluated in 86 patients and compared with the Friedewald equation and the ultracentrifugation procedure.
Results: The alternative equations yield significantly lower bias than the Friedewald equation and are less affected by increased triglycerides (TG) levels.
Conclusion: The alternative equations for LDL-C yield slightly better results than the Friedewald equation especially in hypertriglyceridemia.