The link between IFN-gamma and allograft arteriopathy: is the answer NO?

Richard N Mitchell; Andrew H Lichtman

doi:10.1172/JCI22927

The link between IFN-gamma and allograft arteriopathy: is the answer NO?

J Clin Invest. 2004 Sep;114(6):762-4. doi: 10.1172/JCI22927.

Authors

Richard N Mitchell¹, Andrew H Lichtman

Affiliation

¹ Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

PMID: 15372099
PMCID: PMC516268
DOI: 10.1172/JCI22927

Abstract

Vascularized organ transplants often fail because of smooth muscle cell migration and proliferation in the intima of graft arteries, leading to progressive lumenal narrowing and resultant ischemic damage. Graft arterial disease is caused by IFN-gamma secreted by alloreactive T cells. New evidence indicates that IFN-gamma dysregulates expression of the enzymes eNOS and iNOS in graft-infiltrating leukocytes. Dysregulated NO synthase expression occurs prior to and is causally linked to intimal smooth muscle cell accumulation.

Publication types

Comment
Review

MeSH terms

Arteries / immunology
Arteries / pathology*
Humans
Interferon-gamma / physiology*
Muscle, Smooth, Vascular / enzymology
Nitric Oxide / physiology*
Nitric Oxide Synthase / genetics
Nitric Oxide Synthase / immunology
Nitric Oxide Synthase Type II
Nitric Oxide Synthase Type III
Transplantation, Homologous / immunology*
Transplantation, Homologous / pathology*

Substances

Nitric Oxide
Interferon-gamma
NOS2 protein, human
NOS3 protein, human
Nitric Oxide Synthase
Nitric Oxide Synthase Type II
Nitric Oxide Synthase Type III