Abstract
We report the case of a child with Philadelphia chromosome-negative bilineage leukemia characterized by the coexistence of T-cell leukemia and myelomonocytic leukemia. Comparative analyses of genetic markers and proliferative/differentiative potential show the possibility of malignant transformation of a T-lineage stem cell with the potential to differentiate into the myeloid lineage.
Publication types
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Case Reports
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Antigens, CD / analysis
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Base Sequence
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Cell Differentiation
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Cell Lineage*
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Cell Transformation, Neoplastic / genetics
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Cell Transformation, Neoplastic / pathology
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CpG Islands
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Fatal Outcome
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Hematopoietic Stem Cells / chemistry
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Hematopoietic Stem Cells / pathology*
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Humans
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Leukemia, Myelomonocytic, Acute / pathology*
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Leukemia-Lymphoma, Adult T-Cell / pathology*
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Male
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Models, Biological
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Molecular Sequence Data
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Neoplastic Stem Cells / chemistry
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Neoplastic Stem Cells / pathology*
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Time Factors