Morphometry of the superior temporal plane in schizophrenia: relationship to clinical correlates

J Neuropsychiatry Clin Neurosci. 2004 Summer;16(3):284-94. doi: 10.1176/jnp.16.3.284.

Abstract

A magnetic-resonance-imaging-based method of cortical parcellation was used to evaluate the morphology of the superior temporal plane and its subregions (Heschl's gyrus [HG], planum temporale [PT], and planum polare [PP]) in a group of 30 patients with schizophrenia versus a matched group of healthy subjects. Right HG volume was significantly reduced in patients compared with control subjects. Each subregion showed a unique set of structure/function relationships: reduced volumes of the HG were associated with greater duration of illness; reduced volumes of the PT were associated with positive symptoms; and in most contrast, elevated volumes of the PP were associated with cumulative neuroleptic exposure.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Brain Mapping
  • Case-Control Studies
  • Demography
  • Female
  • Functional Laterality / physiology
  • Humans
  • Image Processing, Computer-Assisted / methods
  • Magnetic Resonance Imaging / methods*
  • Male
  • Psychiatric Status Rating Scales
  • Reproducibility of Results
  • Schizophrenia / pathology*
  • Temporal Lobe / pathology*