Abstract
The focus of this review is the influence of an immunosuppressive xenobiotic drug mycophenolic acid on the induction of nitric oxide production in various cell types. The potential therapeutic significance of the cell-specific fine-tuning of nitric oxide release by mycophenolic acid, as well as the mechanisms behind the drug action are discussed.
MeSH terms
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Animals
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Autoimmune Diseases / drug therapy*
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Autoimmune Diseases / enzymology
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Autoimmune Diseases / immunology
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Cells, Cultured
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Enzyme Inhibitors / pharmacology*
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Enzyme Inhibitors / therapeutic use
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Humans
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Immunosuppressive Agents / pharmacology*
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Immunosuppressive Agents / therapeutic use
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Mycophenolic Acid / pharmacology*
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Mycophenolic Acid / therapeutic use
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Nitric Oxide / biosynthesis*
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Nitric Oxide Synthase / antagonists & inhibitors*
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Nitric Oxide Synthase Type II
Substances
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Enzyme Inhibitors
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Immunosuppressive Agents
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Nitric Oxide
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NOS2 protein, human
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Nitric Oxide Synthase
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Nitric Oxide Synthase Type II
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Mycophenolic Acid