Abstract
A 88-year-old man with prostate cancer was receiving non-steroidal anti-androgen therapy (flutamide, 375 mg/day). Three weeks after starting therapy, the patient developed dyspnea and bilateral pulmonary interstitial infiltrates. The withdrawal of flutamide and the initiation of steroid therapy resulted in clinical improvement.
MeSH terms
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Adenocarcinoma / drug therapy*
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Aged
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Aged, 80 and over
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Antineoplastic Agents, Hormonal / adverse effects*
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Antineoplastic Agents, Hormonal / therapeutic use
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Flutamide / adverse effects*
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Flutamide / therapeutic use
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Humans
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Lung Diseases, Interstitial / chemically induced*
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Lung Diseases, Interstitial / diagnostic imaging
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Male
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Prednisolone / therapeutic use
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Prostatic Neoplasms / drug therapy*
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Radiography, Thoracic
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Retreatment
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Tomography, X-Ray Computed
Substances
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Antineoplastic Agents, Hormonal
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Flutamide
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Prednisolone