Abstract
A synthetic benz[f]indole-4,9-dione analog, 2-amino-3-ethoxycarbonyl-N-methylbenz[f]indole-4,9-dione (SME-6), showed a potent growth inhibition of a panel of human cancer cell lines. The mechanism of action study revealed that the growth inhibitory effect of SME-6 was highly related to the induction of G2/M cell cycle arrest and apoptosis in human lung cancer cells (A549). These data may provide new information for understanding the mechanisms by benz[f]indole-4,9-diones-mediated antitumor activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Apoptosis / drug effects*
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Apoptosis / physiology
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Cell Division / drug effects*
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Cell Division / physiology
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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G2 Phase / drug effects*
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G2 Phase / physiology
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Humans
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Imidazoles / chemical synthesis*
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Imidazoles / chemistry
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Imidazoles / pharmacology
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Lung Neoplasms
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Microscopy, Electron, Scanning
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Microscopy, Fluorescence
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Naphthoquinones / chemical synthesis*
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Naphthoquinones / chemistry
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Naphthoquinones / pharmacology
Substances
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2-amino-3-ethoxycarbonyl-N-methylbenz(f)indole-4,9-dione
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Antineoplastic Agents
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Imidazoles
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Naphthoquinones