Abstract
We demonstrated that trifluoperazine, a calcium-calmodulin antagonist, blocked the hyperpermeability induced by Vibrio vulnificus cytolysin in in vitro-modeled endothelium and prevented the deaths of mice. Furthermore, compared to tetracycline alone, tetracycline combined with trifluoperazine enhanced the survival rate of V. vulnificus-infected mice, indicating the role of the cytolysin as an important factor in pathogenesis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Albumins / metabolism
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Animals
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Calcium / antagonists & inhibitors*
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Calcium / metabolism
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Calmodulin / antagonists & inhibitors*
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Calmodulin / metabolism
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Capillary Permeability / drug effects*
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Cell Line
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Cytotoxins / antagonists & inhibitors*
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Cytotoxins / pharmacology
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Endothelial Cells / drug effects
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Endothelial Cells / metabolism
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Mice
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Models, Animal*
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Protein Transport / drug effects
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Trifluoperazine / pharmacology*
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Vibrio vulnificus / chemistry
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Vibrio vulnificus / pathogenicity*
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Vibrio vulnificus / physiology
Substances
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Albumins
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Calmodulin
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Cytotoxins
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Trifluoperazine
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Calcium