Abstract
In a cross-sectional survey of 187 Gambian children and adults, we have analyzed prevalence, fine specificity, and 19-kilodalton merozoite surface protein 1 (MSP-1(19))-specific erythrocyte invasion inhibitory activity of antibodies to MSP-1(19) but find no significant association between any of these parameters and prevalence or density of malarial parasitemia, except that, after correcting for total anti-MSP-1(19) antibody levels, individuals with anti-MSP-1(19) antibodies that compete with an invasion inhibitory monoclonal antibody (12.10) were significantly less likely to have malaria infections with densities of > or =1,000 parasites/microl than were individuals without such antibodies. This association persisted after correction for age and ethnic origin.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adolescent
-
Adult
-
Aging / physiology
-
Animals
-
Antibodies, Protozoan / immunology*
-
Antibody Specificity / immunology*
-
Child
-
Child, Preschool
-
Cross-Sectional Studies
-
Ethnicity
-
Gambia / epidemiology
-
Gambia / ethnology
-
Humans
-
Infant
-
Infant, Newborn
-
Logistic Models
-
Malaria, Falciparum / epidemiology
-
Malaria, Falciparum / immunology*
-
Malaria, Falciparum / parasitology
-
Malaria, Falciparum / prevention & control
-
Merozoite Surface Protein 1 / chemistry*
-
Merozoite Surface Protein 1 / immunology*
-
Molecular Weight
-
Parasitemia / epidemiology
-
Parasitemia / immunology
-
Parasitemia / parasitology
-
Parasitemia / prevention & control*
-
Plasmodium falciparum / chemistry
-
Plasmodium falciparum / immunology*
-
Prevalence
Substances
-
Antibodies, Protozoan
-
Merozoite Surface Protein 1