Abstract
Two new decalin derivatives, eujavanoic acids A (1) and B (2), were isolated from Eupenicillium javanicum, along with several compactin derivatives. The structures of 1 and 2 were determined by spectroscopic methods and modified Mosher's method. The side chain (2-methylbutanoyloxy) and acid functionalities of compactin derivatives were necessary to show the antifungal activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology
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Ascomycota / chemistry*
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Aspergillus fumigatus / drug effects
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Candida albicans / drug effects
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Cryptococcus neoformans / drug effects
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Lovastatin / analogs & derivatives*
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Lovastatin / chemistry
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Lovastatin / pharmacology
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Molecular Conformation
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Molecular Structure
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Naphthalenes / chemistry
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Naphthalenes / isolation & purification*
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Naphthalenes / pharmacology
Substances
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Antifungal Agents
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Naphthalenes
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eujavanoic acid A
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eujavanoic acid B
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mevastatin
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decalin
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Lovastatin