Regulation of the expression of the rat angiotensin II receptor mRNA

Biochem Biophys Res Commun. 1992 Feb 14;182(3):1094-9. doi: 10.1016/0006-291x(92)91844-g.

Abstract

Regulation of the expression levels of the rat angiotensin II receptor mRNA in the adrenal, aorta, kidney, and brain was assessed by the competitive polymerase chain reaction method. The bilateral nephrectomy or the administration of Dup753 markedly reduced the expression levels of this receptor mRNA in the adrenal and brain stem, but not in the kidney nor aorta. A continuous infusion of angiotensin II increased the expression level of this receptor mRNA in the adrenal but not in the other tissues. It is suggested that the expression level of this receptor mRNA in the adrenal is dependent on the renin angiotensin aldosterone system.

Publication types

  • Comparative Study

MeSH terms

  • Actins / genetics
  • Adrenal Glands / physiology*
  • Angiotensin II / metabolism*
  • Animals
  • Aorta / physiology*
  • Biphenyl Compounds / pharmacology
  • Brain Stem / physiology*
  • Cell Line
  • Chromosome Deletion
  • Gene Expression Regulation* / drug effects
  • Imidazoles / pharmacology
  • Kidney / physiology*
  • Losartan
  • Muscle, Smooth, Vascular / physiology
  • Nephrectomy
  • Organ Specificity
  • Polymerase Chain Reaction
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism*
  • Rats
  • Receptors, Angiotensin / genetics*
  • Tetrazoles / pharmacology

Substances

  • Actins
  • Biphenyl Compounds
  • Imidazoles
  • RNA, Messenger
  • Receptors, Angiotensin
  • Tetrazoles
  • Angiotensin II
  • Losartan