Abstract
Peritoneal exudate macrophages from C3H/OuJ (Lpsn) and C3H/HeJ (Lpsd) mice were treated with interferon alpha (IFN-alpha), and isotype-specific phagocytosis and gene expression were measured. IFN-alpha selectively augments phagocytosis of IgG2a, with a highly significant induction of Fc gamma RI mRNA expression, while parallel Fc gamma RIII alpha measurements show a relatively small increase.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Antibody Specificity
-
Female
-
Immunoglobulin Isotypes / immunology*
-
Interferon-alpha / pharmacology*
-
Macrophages / immunology*
-
Mice
-
Mice, Inbred C3H
-
Phagocytosis / immunology*
-
RNA, Messenger / analysis
-
RNA, Messenger / drug effects
-
Receptors, Fc / genetics*
-
Receptors, Fc / physiology
Substances
-
Immunoglobulin Isotypes
-
Interferon-alpha
-
RNA, Messenger
-
Receptors, Fc