Abstract
Three males with factor-IX deficiency (Christmas disease) in one pedigree all had severe affective disorder. This apparent cosegregation, if true, would support the hypothesis that in some pedigrees, a gene for major affective disorder is located on the X chromosome.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Bipolar Disorder / genetics*
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Bipolar Disorder / psychology
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Depressive Disorder / genetics*
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Depressive Disorder / psychology
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Genetic Carrier Screening
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Genetic Linkage / genetics*
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Hemophilia B / genetics*
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Hemophilia B / psychology
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Humans
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Male
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Pedigree
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Sex Chromosome Aberrations / genetics*
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Sex Chromosome Aberrations / psychology
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X Chromosome*