Abstract
A series of xanthine oxidase-activated prodrugs of known inhibitors of thymidine phosphorylase has been designed and synthesised to introduce tumour selectivity. These prodrugs were oxidised by xanthine oxidase at C-2 and/or C-4 of the uracil ring to generate the desired TP inhibitor.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Escherichia coli / enzymology
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Humans
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Prodrugs / chemical synthesis*
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Prodrugs / chemistry
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Pyrimidines / chemical synthesis*
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Pyrimidines / chemistry
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Pyrroles / chemical synthesis*
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Pyrroles / chemistry
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Pyrrolidines / chemical synthesis*
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Pyrrolidines / chemistry
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Thymidine Phosphorylase / antagonists & inhibitors*
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Thymidine Phosphorylase / chemistry
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Xanthine Oxidase / chemistry*
Substances
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Antineoplastic Agents
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Prodrugs
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Pyrimidines
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Pyrroles
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Pyrrolidines
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Xanthine Oxidase
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Thymidine Phosphorylase