Loops on loops: generation of complex scaffolded peptides presenting multiple cyclic fragments

Org Biomol Chem. 2004 Oct 7;2(19):2847-51. doi: 10.1039/B403720K. Epub 2004 Sep 6.

Abstract

Scaffolded peptides presenting two different cyclic peptide fragments through a cyclic peptidomimetic scaffold in a site-selective fashion, were generated by stepwise solid phase synthesis and fragment condensation in parallel, demonstrating that either strategy is adequate to generate complex scaffolded peptides.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomimetic Materials / chemical synthesis*
  • Chromatography, High Pressure Liquid
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Peptide Fragments / chemical synthesis*
  • Peptide Fragments / chemistry
  • Peptides / chemical synthesis*
  • Peptides, Cyclic / chemical synthesis*
  • Peptides, Cyclic / chemistry

Substances

  • Peptide Fragments
  • Peptides
  • Peptides, Cyclic