Abstract
We report a rare case of malignant lymphoma arising from the posterior mediastinum with bilateral pleural effusion. A 71-year-old man was admitted to our hospital for evaluation of a posterior mediastinal tumor and bilateral pleural effusion revealed on a chest CT scan. Because no tumor tissue could be obtained by fiberbronchoscopy, video-assisted thoracoscopic surgery was performed. The tumor sample was composed of large, atypical lymphocytes positive for CD20 on immunohistochemical analysis. A diagnosis of diffuse large B cell lymphoma was made from the typical histological features. The patient was treated with combination chemotherapy (CHOP) and rituximab and improved dramatically.
Publication types
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Case Reports
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English Abstract
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Review
MeSH terms
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Aged
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Antibodies, Monoclonal / administration & dosage
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Antibodies, Monoclonal, Murine-Derived
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Antigens, CD20 / analysis
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Biomarkers, Tumor / analysis
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Biopsy / methods
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Cyclophosphamide / administration & dosage
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Doxorubicin / administration & dosage
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Humans
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Lymphoma, B-Cell / complications*
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Lymphoma, B-Cell / diagnosis*
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Lymphoma, B-Cell / drug therapy
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Lymphoma, Large B-Cell, Diffuse / complications*
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Lymphoma, Large B-Cell, Diffuse / diagnosis*
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Lymphoma, Large B-Cell, Diffuse / drug therapy
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Male
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Mediastinal Neoplasms / complications*
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Mediastinal Neoplasms / diagnosis*
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Mediastinal Neoplasms / drug therapy
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Pleural Effusion, Malignant / complications*
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Pleural Effusion, Malignant / drug therapy
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Prednisolone / administration & dosage
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Rituximab
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Thoracic Surgery, Video-Assisted
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Tomography, X-Ray Computed
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Treatment Outcome
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Vincristine / administration & dosage
Substances
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Antibodies, Monoclonal
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Antibodies, Monoclonal, Murine-Derived
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Antigens, CD20
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Biomarkers, Tumor
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Rituximab
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Vincristine
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Doxorubicin
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Cyclophosphamide
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Prednisolone