Role of T-type calcium current in identified D-hair mechanoreceptor neurons studied in vitro

J Neurosci. 2004 Sep 29;24(39):8480-4. doi: 10.1523/JNEUROSCI.1598-04.2004.

Abstract

Different subsets of dorsal root ganglion (DRG) mechanoreceptors transduce low- and high-intensity mechanical stimuli. It was shown recently that, in vivo, neurotrophin-4 (NT-4)-dependent D-hair mechanoreceptors specifically express a voltage-activated T-type calcium channel (Ca(v)3.2) that may be required for their mechanoreceptive function. Here we show that D-hair mechanoreceptors can be identified in vitro by a rosette-like morphology in the presence of NT-4 and that these rosette neurons are almost all absent in DRG cultures taken from NT-4 knock-out mice. In vitro identification of the D-hair mechanoreceptor allowed us to explore the electrophysiological properties of these cells. We demonstrate that the T-type Ca(v)3.2 channel induced slow membrane depolarization that contributes to lower the voltage threshold for action potential generation and controls spike latency after stimulation of D-hair mechanoreceptors. Indeed, the properties of the T-type amplifier are particularly well suited to explain the high sensitivity of D-hair mechanoreceptors to slowly moving stimuli.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / physiology
  • Aging / physiology
  • Animals
  • Calcium Channels, T-Type / drug effects
  • Calcium Channels, T-Type / physiology*
  • Cell Enlargement
  • Cell Shape
  • Cells, Cultured
  • Female
  • Ganglia, Spinal / cytology
  • Ganglia, Spinal / physiology*
  • Mechanoreceptors / physiology*
  • Mechanoreceptors / ultrastructure
  • Mechanotransduction, Cellular / physiology
  • Membrane Potentials / physiology
  • Mice
  • Mice, Knockout
  • Nerve Growth Factors / genetics
  • Nerve Growth Factors / physiology
  • Neurons / physiology*
  • Neurons / ultrastructure
  • Nickel / pharmacology
  • Patch-Clamp Techniques

Substances

  • Calcium Channels, T-Type
  • Nerve Growth Factors
  • nickel chloride
  • Nickel
  • neurotrophin 4