Post-transcriptional gene silencing in neurons

Henry C Zeringue; Martha Constantine-Paton

doi:10.1016/j.conb.2004.08.009

Post-transcriptional gene silencing in neurons

Curr Opin Neurobiol. 2004 Oct;14(5):654-9. doi: 10.1016/j.conb.2004.08.009.

Authors

Henry C Zeringue¹, Martha Constantine-Paton

Affiliation

¹ Department of Biology, McGovern Institute for Brain Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

PMID: 15464901
DOI: 10.1016/j.conb.2004.08.009

Abstract

The techniques evolving from the rapidly developing field of small RNAs promise accessible approaches to dissecting cellular and molecular mechanisms of higher brain function. Here, a current overview of the technology is presented, along with an outline of how these approaches might help neuroscientists to more rapidly uncover the cellular and molecular bases of behavior.

Publication types

Review

MeSH terms

Animals
Brain / physiology*
Gene Targeting / methods
Gene Targeting / trends
Genetic Vectors / genetics
Humans
Models, Animal
Nerve Tissue Proteins / biosynthesis
Nerve Tissue Proteins / genetics
Neurons / physiology*
RNA Interference / physiology*
RNA, Messenger / genetics
RNA, Messenger / metabolism*
RNA, Small Interfering / genetics*

Substances

Nerve Tissue Proteins
RNA, Messenger
RNA, Small Interfering