Improved method of in vivo respiratory-gated micro-CT imaging

Phys Med Biol. 2004 Sep 7;49(17):4163-72. doi: 10.1088/0031-9155/49/17/023.

Abstract

The presence of motion artifacts is a typical problem in thoracic imaging. However, synchronizing the respiratory cycle with computed tomography (CT) image acquisition can reduce these artifacts. We currently employ a method of in vivo respiratory-gated micro-CT imaging for small laboratory animals (mice). This procedure involves the use of a ventilator that controls the respiratory cycle of the animal and provides a digital output signal that is used to trigger data acquisition. After inspection of the default respiratory trigger timing, we hypothesized that image quality could be improved by moving the data-acquisition window to a portion of the cycle with less respiratory motion. For this reason, we developed a simple delay circuit to adjust the timing of the ventilator signal that initiates micro-CT data acquisition. This delay circuit decreases motion artifacts and substantially improves image quality.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Animals
  • Artifacts
  • Humans
  • Image Processing, Computer-Assisted / methods*
  • Imaging, Three-Dimensional
  • Mice
  • Movement
  • Radiographic Image Enhancement
  • Radiographic Image Interpretation, Computer-Assisted / methods*
  • Respiration
  • Time Factors
  • Tomography, X-Ray Computed / instrumentation*
  • Tomography, X-Ray Computed / methods*