A novel complex t(2;5;13)(p23;q35;q14) in small cell variant type anaplastic large cell lymphoma with peripheral involvement

Sun-Young Kong; Hyun-Jung Cho; Jung-Ho Suk; Eun-Young Tak; Young Hyeh Ko; Kihyun Kim; Sun-Hee Kim

doi:10.1016/j.cancergencyto.2004.03.004

A novel complex t(2;5;13)(p23;q35;q14) in small cell variant type anaplastic large cell lymphoma with peripheral involvement

Cancer Genet Cytogenet. 2004 Oct 15;154(2):183-5. doi: 10.1016/j.cancergencyto.2004.03.004.

Authors

Sun-Young Kong¹, Hyun-Jung Cho, Jung-Ho Suk, Eun-Young Tak, Young Hyeh Ko, Kihyun Kim, Sun-Hee Kim

Affiliation

¹ Department of Laboratory Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, 50 Ilwon-dong, Gangnam-gu, Seoul, Republic of Korea.

PMID: 15474159
DOI: 10.1016/j.cancergencyto.2004.03.004

Abstract

We report the case of a 32-year-old woman who was diagnosed as having small cell variant type anaplastic large cell lymphoma with peripheral involvement. A cytogenetic study showed a complex translocation, t(2;5;13)(p23;q35;q14). Fluorescence in situ hybridization with ALK break-apart probes confirmed that the three-break rearrangement involves the ALK gene.

Publication types

Case Reports

MeSH terms

Adult
Anaplastic Lymphoma Kinase
Chromosomes, Human, Pair 2*
Chromosomes, Human, Pair 5*
Female
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Lymphoma, Large B-Cell, Diffuse / genetics*
Lymphoma, Large B-Cell, Diffuse / pathology
Protein-Tyrosine Kinases / genetics
Receptor Protein-Tyrosine Kinases
Translocation, Genetic

Substances

ALK protein, human
Anaplastic Lymphoma Kinase
Protein-Tyrosine Kinases
Receptor Protein-Tyrosine Kinases