Histopathologic verification of acute leukemia (AL) in a cohort of 463 post-Chernobyl patients from Belarus, Russia and Ukraine

Philip L McCarthy Jr; Ora Paltiel; Elena Maslova; Sergei Kulikov; Theresa Hahn; Kenneth J Kopecky; Vera Drozdova; Natalya Shmatina; Ludmilla Tichonova; Jack Van Hoff; Inna Gavrilova; Howard Weinstein

doi:10.1016/j.leukres.2004.04.008

Histopathologic verification of acute leukemia (AL) in a cohort of 463 post-Chernobyl patients from Belarus, Russia and Ukraine

Leuk Res. 2004 Dec;28(12):1273-80. doi: 10.1016/j.leukres.2004.04.008.

Authors

Philip L McCarthy Jr¹, Ora Paltiel, Elena Maslova, Sergei Kulikov, Theresa Hahn, Kenneth J Kopecky, Vera Drozdova, Natalya Shmatina, Ludmilla Tichonova, Jack Van Hoff, Inna Gavrilova, Howard Weinstein

Affiliation

¹ Department of Medicine, Blood and Marrow Transplant Section, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. [email protected]

PMID: 15475068
DOI: 10.1016/j.leukres.2004.04.008

Abstract

Seven morphologists examined 382 slide and 82 non-slide, post-Chernobyl pediatric acute leukemia (AL) cases in radiation-exposed areas of Belarus, Russia and Ukraine; part of a case-control study by the International Consortium for Research on the Health Effects of Radiation. Among the slide cases, 99% were confirmed as AL: 92% acute lymphoid leukemia (ALL) and 86% acute myeloid leukemia (AMD demonstrating the utility of FAB classification for distinguishing ALL and AML. Among the non-slide cases, 79% were confirmed as AL: 84% ALL, and 71% AML. This study affirms AL diagnostic accuracy during a time of social upheaval in the former Soviet Union.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Acute Disease
Case-Control Studies
Chernobyl Nuclear Accident*
Diagnostic Techniques and Procedures / standards
Histological Techniques / standards
Humans
Leukemia / classification*
Leukemia / diagnosis*
Reproducibility of Results
Republic of Belarus
Russia
Ukraine