Biomedicine. Insulin resistance takes a trip through the ER

Science. 2004 Oct 15;306(5695):425-6. doi: 10.1126/science.1104680.
No abstract available

Publication types

  • Comment

MeSH terms

  • Adipose Tissue / metabolism
  • Animals
  • Cells, Cultured
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism
  • Endoplasmic Reticulum / metabolism*
  • Endoribonucleases
  • Enzyme Activation
  • Homeostasis
  • Humans
  • Insulin / metabolism*
  • Insulin Receptor Substrate Proteins
  • Insulin Resistance / physiology*
  • Islets of Langerhans / metabolism
  • Liver / metabolism
  • Membrane Proteins / metabolism
  • Mice
  • Mitogen-Activated Protein Kinase 8
  • Mitogen-Activated Protein Kinases / metabolism*
  • Muscle, Skeletal / metabolism
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism
  • Obesity / metabolism*
  • Phosphoproteins / metabolism
  • Phosphorylation
  • Protein Serine-Threonine Kinases / metabolism
  • Regulatory Factor X Transcription Factors
  • Signal Transduction
  • Transcription Factors
  • eIF-2 Kinase / metabolism

Substances

  • DNA-Binding Proteins
  • IRS1 protein, human
  • Insulin
  • Insulin Receptor Substrate Proteins
  • Irs1 protein, mouse
  • Membrane Proteins
  • Nuclear Proteins
  • Phosphoproteins
  • Regulatory Factor X Transcription Factors
  • Transcription Factors
  • ERN2 protein, human
  • Ern2 protein, mouse
  • PERK kinase
  • Protein Serine-Threonine Kinases
  • eIF-2 Kinase
  • Mitogen-Activated Protein Kinase 8
  • Mitogen-Activated Protein Kinases
  • Endoribonucleases