Abstract
Tubulin is known to form high-affinity complexes with certain G proteins. The formation of such complexes allows tubulin to activate Galpha and fosters a system whereby elements of the cytoskeleton can influence G-protein signaling. This article describes the interaction between tubulin and G proteins and discusses methods for examining this interaction.
MeSH terms
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Animals
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Cell Line
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Cell Membrane / chemistry
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Cell Membrane / metabolism
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Cytoskeleton / metabolism
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Enzyme Activation
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GTP-Binding Protein alpha Subunits / genetics
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GTP-Binding Protein alpha Subunits / metabolism
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GTP-Binding Proteins / genetics
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GTP-Binding Proteins / metabolism*
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Glioma / metabolism
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Guanosine Triphosphate / analogs & derivatives
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Guanosine Triphosphate / metabolism
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Isoenzymes / metabolism
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Phospholipase C beta
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Protein Binding
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Rats
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Recombinant Fusion Proteins / genetics
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Recombinant Fusion Proteins / metabolism
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Second Messenger Systems / physiology*
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Tubulin / metabolism*
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Type C Phospholipases / metabolism
Substances
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GTP-Binding Protein alpha Subunits
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Isoenzymes
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Recombinant Fusion Proteins
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Tubulin
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Guanosine Triphosphate
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Type C Phospholipases
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Phospholipase C beta
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GTP-Binding Proteins