Abstract
Chromosomal translocations involving immunoglobulin switch regions are commonly thought to arise from aberrant AID-induced DNA lesions. New data, however, suggest AID does not initiate such lesions, but acts subsequently in the B cell transformation process.
MeSH terms
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AICDA (Activation-Induced Cytidine Deaminase)
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Animals
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Antibodies / genetics
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Cytidine Deaminase
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Cytosine Deaminase / metabolism
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DNA Glycosylases / genetics
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DNA Glycosylases / metabolism
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Genes, myc*
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Humans
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Immunoglobulin Class Switching / genetics*
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Immunoglobulin Class Switching / physiology
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Mutation
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Receptors, Antigen, B-Cell / genetics
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Translocation, Genetic* / physiology
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Uracil-DNA Glycosidase
Substances
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Antibodies
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Receptors, Antigen, B-Cell
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DNA Glycosylases
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Uracil-DNA Glycosidase
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AICDA (Activation-Induced Cytidine Deaminase)
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Cytosine Deaminase
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Cytidine Deaminase