L protein, the RNA-dependent RNA polymerase of hantaviruses

Arch Virol. 2005 Mar;150(3):533-56. doi: 10.1007/s00705-004-0414-8. Epub 2004 Oct 20.

Abstract

L protein of hantaviruses is the RNA transcriptase and replicase that transcribes mRNAs and replicates the genomic RNA using antigenomic RNA as an intermediate. It also appears to have endonuclease activity. In this review, the current knowledge on the hantavirus L protein is presented including sequence motifs conserved in RNA polymerases, mechanisms of RNA synthesis and also the most recent findings on homologous RNA recombination and membrane association.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Amino Acid Motifs
  • Amino Acid Sequence
  • Animals
  • Cell Membrane / virology
  • Cell Nucleus / virology
  • Chlorocebus aethiops
  • Genetic Variation
  • Molecular Sequence Data
  • Orthohantavirus / enzymology
  • Orthohantavirus / genetics
  • Orthohantavirus / physiology*
  • RNA, Viral / biosynthesis
  • RNA-Dependent RNA Polymerase / chemistry
  • RNA-Dependent RNA Polymerase / genetics
  • RNA-Dependent RNA Polymerase / physiology*
  • Sequence Alignment
  • Transcription, Genetic
  • Vero Cells
  • Viral Proteins / chemistry
  • Viral Proteins / physiology*
  • Virus Replication

Substances

  • RNA, Viral
  • Viral Proteins
  • L protein, hantavirus
  • RNA-Dependent RNA Polymerase