Topical application of nerve growth factor in human diabetic foot ulcers. A study of three cases

S Generini; M A Tuveri; M Matucci Cerinic; F Mastinu; L Manni; L Aloe

doi:10.1055/s-2004-821313

Topical application of nerve growth factor in human diabetic foot ulcers. A study of three cases

Exp Clin Endocrinol Diabetes. 2004 Oct;112(9):542-4. doi: 10.1055/s-2004-821313.

Authors

S Generini¹, M A Tuveri, M Matucci Cerinic, F Mastinu, L Manni, L Aloe

Affiliation

¹ Department of Medicine, Section of Rheumatology, University of Florence, Italy.

PMID: 15505764
DOI: 10.1055/s-2004-821313

Abstract

Three diabetic patients with leg or foot ulcers unresponsive to conventional therapies were treated with topical application of Nerve Growth Factor (NGF). The results showed that NGF promotes healing after 5-14 weeks of treatment. This study suggests that the use of topical application of NGF may represent a new useful tool for the management of difficult diabetic ulcers.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Administration, Topical
Aged
Diabetic Foot / drug therapy*
Diabetic Foot / physiopathology
Drug Administration Schedule
Female
Humans
Male
Middle Aged
Nerve Growth Factor / administration & dosage*
Nerve Growth Factor / therapeutic use
Treatment Outcome
Wound Healing / drug effects

Substances

Nerve Growth Factor