An unusual case of Behçet's syndrome: triggered by typhoid vaccination?

E S Molloy; F C Powell; M F Doran; J G Ryan; N J Mulligan; C J McCarthy; M T Keogan; G M McCarthy

An unusual case of Behçet's syndrome: triggered by typhoid vaccination?

Clin Exp Rheumatol. 2004 Jul-Aug;22(4 Suppl 34):S71-4.

Authors

E S Molloy¹, F C Powell, M F Doran, J G Ryan, N J Mulligan, C J McCarthy, M T Keogan, G M McCarthy

Affiliation

¹ Department of Rheumatology, Mater Misericordiae Hospital, Dublin, Ireland. [email protected]

PMID: 15515791

Abstract

A case of Behçet's syndrome in a 32-year-old woman occurring shortly after her third vaccination against typhoid fever is described. Scleritis and pyoderma gangrenosum were unusual manifestations of BS that occurred in this case. Treatment benefit was provided by mycophenolate mofetil and etanercept. As bacterial antigens have been proposed as potential triggers for the onset of BS, it is possible that the syndrome was precipitated by typhoid vaccination in this patient.

Publication types

Case Reports

MeSH terms

Adult
Behcet Syndrome / complications
Behcet Syndrome / etiology*
Behcet Syndrome / pathology
Etanercept
Female
Humans
Immunoglobulin G / therapeutic use
Immunosuppressive Agents / therapeutic use
Mycophenolic Acid / analogs & derivatives*
Mycophenolic Acid / therapeutic use
Pyoderma Gangrenosum / drug therapy
Pyoderma Gangrenosum / etiology
Pyoderma Gangrenosum / pathology
Receptors, Tumor Necrosis Factor / therapeutic use
Scleritis / drug therapy
Scleritis / etiology
Scleritis / pathology
Treatment Outcome
Typhoid Fever / prevention & control*
Typhoid-Paratyphoid Vaccines / adverse effects*
Vaccination / adverse effects*

Substances

Immunoglobulin G
Immunosuppressive Agents
Receptors, Tumor Necrosis Factor
Typhoid-Paratyphoid Vaccines
Mycophenolic Acid
Etanercept