Abstract
Preparative scale fermentation of (6S)-dihydrokawain (1) with Rhizopus arrhizus (ATCC 11145) gave 3'-hydroxydihydrokawain (2) and (8S)-hydroxydihydrokawain (3). Structure elucidation of the metabolites was based on spectroscopic data. The C-8 absolute configuration of (3) was assessed via its Mosher's esters.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Kava / metabolism*
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Kava / microbiology*
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Plant Components, Aerial / microbiology
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Plant Extracts / isolation & purification
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Plant Extracts / metabolism
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Pyrones / isolation & purification
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Pyrones / metabolism*
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Rhizopus / isolation & purification
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Rhizopus / metabolism*
Substances
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Plant Extracts
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Pyrones
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dihydrokawain-5-ol