Comparison of outcomes in acute coronary syndrome in patients receiving statins within 24 hours of onset versus at later times

Am J Cardiol. 2004 Nov 1;94(9):1166-8. doi: 10.1016/j.amjcard.2004.07.085.

Abstract

The clinical benefits of statins in acute coronary syndromes are well established, but the optimal time for administration in this setting has not been well studied. In this study, patients who had acute coronary syndrome and received statins <24 hours of presentation had lower incidences of death, stroke, reinfarction, heart failure, and pulmonary edema compared with delayed administration. Prompt administration of statins appears to be significantly beneficial in patients who present with an acute coronary syndrome.

Publication types

  • Comparative Study

MeSH terms

  • Adrenergic beta-Antagonists / therapeutic use
  • Aged
  • Angina, Unstable / drug therapy
  • Angina, Unstable / mortality
  • Angiotensin-Converting Enzyme Inhibitors / therapeutic use
  • Coronary Disease / drug therapy*
  • Coronary Disease / mortality
  • Female
  • Follow-Up Studies
  • Hospital Mortality
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
  • Male
  • Michigan
  • Middle Aged
  • Multivariate Analysis
  • Myocardial Infarction / drug therapy
  • Myocardial Infarction / mortality
  • Syndrome
  • Time Factors
  • Treatment Outcome

Substances

  • Adrenergic beta-Antagonists
  • Angiotensin-Converting Enzyme Inhibitors
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors