Combined effects of smoking and hypercholesterolemia on inflammatory process, thrombosis/fibrinolysis system, and forearm hyperemic response

Am J Cardiol. 2004 Nov 1;94(9):1181-4. doi: 10.1016/j.amjcard.2004.07.090.

Abstract

The combined effects of smoking and hypercholesterolemia on the inflammatory process, the thrombosis/fibrinolysis system, and forearm hyperemic response were investigated. It was shown that smokers with hypercholesterolemia (n = 25) had a reduced and delayed forearm hyperemic response compared with healthy smokers (n = 24), patients with hypercholesterolemia (n = 26), and healthy controls (n = 75; p <0.01 for all). This phenomenon was associated with a respective increase in the inflammatory process and changes in the thrombosis/fibrinolysis system.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Biomarkers / blood
  • C-Reactive Protein / metabolism
  • Cholesterol / metabolism
  • Female
  • Fibrinolysis / physiology*
  • Forearm / blood supply*
  • Forearm / physiopathology
  • Humans
  • Hypercholesterolemia / epidemiology
  • Hypercholesterolemia / metabolism*
  • Hypercholesterolemia / physiopathology
  • Hyperemia / epidemiology
  • Hyperemia / metabolism*
  • Hyperemia / physiopathology
  • Inflammation Mediators / metabolism*
  • Interleukin-6 / metabolism
  • Male
  • Regional Blood Flow / physiology
  • Risk Factors
  • Smoking / epidemiology
  • Smoking / metabolism*
  • Smoking / physiopathology
  • Statistics as Topic
  • Thrombosis / epidemiology
  • Thrombosis / metabolism*
  • Thrombosis / physiopathology
  • Tumor Necrosis Factor-alpha / metabolism
  • Vasodilation / physiology

Substances

  • Biomarkers
  • Inflammation Mediators
  • Interleukin-6
  • Tumor Necrosis Factor-alpha
  • C-Reactive Protein
  • Cholesterol