Abstract
Thirty-six isolates of carbapenem-resistant Pseudomonas aeruginosa were studied. Pulsed-field gel electrophoresis revealed the presence of two clones. One clone carried a bla(IMP-1) gene identical to that first described in Japan. The other clone carried a bla(IMP-1) variant containing four silent mutations. One isolate with a unique pulsed-field gel electrophoresis pattern contained bla(IMP-7).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Carbapenems / pharmacology
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Electrophoresis, Gel, Pulsed-Field
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Hospitals*
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Humans
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Mutation
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Pseudomonas Infections / epidemiology*
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Pseudomonas Infections / microbiology
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Pseudomonas Infections / transmission
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Pseudomonas aeruginosa / drug effects
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Pseudomonas aeruginosa / enzymology
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Pseudomonas aeruginosa / genetics*
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Sequence Analysis, DNA
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Singapore / epidemiology
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beta-Lactam Resistance*
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beta-Lactamases / genetics
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beta-Lactamases / metabolism*
Substances
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Anti-Bacterial Agents
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Carbapenems
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beta-lactamase IMP-1
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beta-Lactamases
Associated data
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GENBANK/AY168635
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GENBANK/AY625685
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GENBANK/AY625686
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GENBANK/AY625687
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GENBANK/AY625688
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GENBANK/AY625689