Cell signalling: IP3 receptors channel calcium into cell death

Curr Biol. 2004 Nov 9;14(21):R933-5. doi: 10.1016/j.cub.2004.10.019.

Abstract

There is substantial evidence that Ca2+ fluxes occur during most forms of apoptosis, and that inhibiting such fluxes protects cells from death. IP3 receptors--ligand-gated channels that release Ca2+ from intracellular stores--are emerging as key sites for regulation by pro- and anti-apoptotic factors.

Publication types

  • Review

MeSH terms

  • Apoptosis / physiology*
  • Apoptosis Regulatory Proteins
  • Bcl-2-Like Protein 11
  • Calcium / metabolism*
  • Calcium / physiology
  • Calcium Channels / metabolism*
  • Carrier Proteins / metabolism
  • Cytosol / metabolism
  • Inositol 1,4,5-Trisphosphate Receptors
  • Membrane Proteins / metabolism
  • Mitochondria / metabolism
  • Proto-Oncogene Proteins / metabolism
  • Receptors, Cytoplasmic and Nuclear / metabolism*
  • Signal Transduction / physiology*

Substances

  • Apoptosis Regulatory Proteins
  • Bcl-2-Like Protein 11
  • Calcium Channels
  • Carrier Proteins
  • Inositol 1,4,5-Trisphosphate Receptors
  • Membrane Proteins
  • Proto-Oncogene Proteins
  • Receptors, Cytoplasmic and Nuclear
  • Calcium