Abstract
To what extent are the pathways that regulate self-renewal conserved between stem cells at different stages of development and in different tissues? Some pathways play a strikingly conserved role in regulating the self-renewal of diverse stem cells, whereas other pathways are specific to stem cells in certain tissues or at certain stages of development. Recent studies have highlighted differences between the self-renewal of embryonic, fetal and adult stem cells. By understanding these similarities and differences we may come to a molecular understanding of how stem cells replicate themselves and why aspects of this process differ between stem cells.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Cell Cycle
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Cell Lineage
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Cell Proliferation
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Drosophila Proteins / metabolism
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Embryo, Mammalian / cytology*
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Hedgehog Proteins
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Humans
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Intercellular Signaling Peptides and Proteins / metabolism
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Membrane Proteins / metabolism
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Models, Biological
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Polycomb Repressive Complex 1
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Receptors, Notch
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Signal Transduction
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Stem Cells / cytology*
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Stem Cells / physiology*
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Time Factors
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Wnt Proteins
Substances
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Drosophila Proteins
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Hedgehog Proteins
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Intercellular Signaling Peptides and Proteins
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Membrane Proteins
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Pc protein, Drosophila
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Receptors, Notch
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Wnt Proteins
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hh protein, Drosophila
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Polycomb Repressive Complex 1