A modified gonadotropin-releasing hormone (GnRH) antagonist protocol failed to increase clinical pregnancy rates in comparison with the long GnRH protocol

Dimitris Loutradis; Konstantinos Stefanidis; Peter Drakakis; Spyridon Milingos; Aris Antsaklis; Stylianos Michalas

doi:10.1016/j.fertnstert.2004.04.051

A modified gonadotropin-releasing hormone (GnRH) antagonist protocol failed to increase clinical pregnancy rates in comparison with the long GnRH protocol

Fertil Steril. 2004 Nov;82(5):1446-8. doi: 10.1016/j.fertnstert.2004.04.051.

Authors

Dimitris Loutradis, Konstantinos Stefanidis, Peter Drakakis, Spyridon Milingos, Aris Antsaklis, Stylianos Michalas

PMID: 15533377
DOI: 10.1016/j.fertnstert.2004.04.051

Abstract

The purpose of this prospective randomized study was to compare stimulation characteristics and IVF outcomes of the standard long GnRH agonist protocol for ovarian stimulation with a modified GnRH antagonist protocol. Starting GnRH antagonist in a flexible protocol according to the size of the leading follicle, with simultaneous augmentation of 75 IU recombinant FSH, failed to increase clinical pregnancy rates.

Publication types

Clinical Trial
Randomized Controlled Trial

MeSH terms

Adult
Clinical Protocols
Female
Gonadotropin-Releasing Hormone / agonists*
Gonadotropin-Releasing Hormone / analogs & derivatives*
Gonadotropin-Releasing Hormone / antagonists & inhibitors*
Gonadotropin-Releasing Hormone / therapeutic use
Hormone Antagonists / therapeutic use
Humans
Pregnancy
Pregnancy Rate*
Time Factors
Triptorelin Pamoate / therapeutic use

Substances

Hormone Antagonists
Triptorelin Pamoate
Gonadotropin-Releasing Hormone
cetrorelix