Associations between UVR exposure and basal cell carcinoma site and histology

Cancer Lett. 2004 Dec 28;216(2):191-7. doi: 10.1016/j.canlet.2004.08.008.

Abstract

While sunlight is critical in basal cell carcinoma (BCC) pathogenesis the relationship between exposure and tumor site and histology is unclear. We determined if tumor site (trunk or head/neck) or histology (nodular or superficial) is determined by exposure pattern. In 66 cases with truncal and 362 patients with head/neck BCC at first presentation, average hours exposure/year, intermittency score, childhood sunburning and skin type were not significantly associated with tumor site or histology. However, often sunbathing was associated with a five-fold increased risk of truncal BCC. Average sunbathing score was significantly greater in 22 cases with truncal compared with 325 cases with head/neck nodular tumors and also in 44 cases with superficial truncal compared with superficial head/neck BCC. Thus, sunbathing determined tumor site but not histology.

MeSH terms

  • Abdomen*
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Carcinoma, Basal Cell / epidemiology
  • Carcinoma, Basal Cell / etiology
  • Carcinoma, Basal Cell / pathology*
  • England / epidemiology
  • Female
  • Head and Neck Neoplasms / epidemiology
  • Head and Neck Neoplasms / etiology
  • Head and Neck Neoplasms / pathology*
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Risk Factors
  • Sex Factors
  • Skin Neoplasms / epidemiology
  • Skin Neoplasms / etiology
  • Skin Neoplasms / pathology*
  • Sunburn / epidemiology
  • Surveys and Questionnaires
  • Thorax*
  • Ultraviolet Rays*