Acute dysautonomia: complete recovery after two courses of IVIg

Mamiko Ishitobi; Kazuhiro Haginoya; Taro Kitamura; Mitsutoshi Munakata; Hiroyuki Yokoyama; Kazuie Iinuma

doi:10.1016/j.braindev.2004.02.012

Acute dysautonomia: complete recovery after two courses of IVIg

Brain Dev. 2004 Dec;26(8):542-4. doi: 10.1016/j.braindev.2004.02.012.

Authors

Mamiko Ishitobi¹, Kazuhiro Haginoya, Taro Kitamura, Mitsutoshi Munakata, Hiroyuki Yokoyama, Kazuie Iinuma

Affiliation

¹ Department of Pediatrics, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan. [email protected]

PMID: 15533658
DOI: 10.1016/j.braindev.2004.02.012

Abstract

An 11-year-old boy presented with acute dysautonomia manifesting as severe orthostatic hypotension following fever. Serial orthostatic tests with measurement of the coefficient of variation in the R-R intervals showed improvement after one course and complete recovery after two courses of intravenous high-dose immunoglobulin therapy (IVIg). Repeated courses of IVIg should be considered to treat this disorder if spontaneous remission does not occur.

Publication types

Case Reports

MeSH terms

Autoimmune Diseases of the Nervous System / drug therapy*
Autoimmune Diseases of the Nervous System / immunology*
Autoimmune Diseases of the Nervous System / physiopathology
Autonomic Nervous System Diseases / drug therapy*
Autonomic Nervous System Diseases / immunology*
Autonomic Nervous System Diseases / physiopathology
Child
Drug Administration Schedule
Fever / complications
Humans
Hypotension, Orthostatic / etiology
Hypotension, Orthostatic / physiopathology
Immunoglobulins, Intravenous / administration & dosage*
Male
Recovery of Function / drug effects*
Recovery of Function / immunology
Tachycardia / etiology
Tachycardia / physiopathology
Treatment Outcome

Substances

Immunoglobulins, Intravenous