Lack of association between Toll-like receptor 2 polymorphisms and susceptibility to severe disease caused by Staphylococcus aureus

Catrin E Moore; Shelley Segal; Anthony R Berendt; Adrian V S Hill; Nicholas P J Day

doi:10.1128/CDLI.11.6.1194-1197.2004

Lack of association between Toll-like receptor 2 polymorphisms and susceptibility to severe disease caused by Staphylococcus aureus

Clin Diagn Lab Immunol. 2004 Nov;11(6):1194-7. doi: 10.1128/CDLI.11.6.1194-1197.2004.

Authors

Catrin E Moore¹, Shelley Segal, Anthony R Berendt, Adrian V S Hill, Nicholas P J Day

Affiliation

¹ Nuffield Department of Clinical Medicine, University of Oxford, Level 4, John Radcliffe Hospital, Oxford, OX3 9DU United Kingdom. [email protected]

Abstract

To investigate a putative link between genetically determined variations in Toll-like receptor 2 (TLR2) and the occurrence of severe Staphylococcus aureus infection, the functional Arg753Gln single-nucleotide polymorphism and the GT repeat microsatellite in the TLR2 gene were examined in a large case-control study. No associations with disease or mortality attributable to these features were found.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Case-Control Studies
Child
Child, Preschool
Female
Genetic Predisposition to Disease*
Humans
Infant
Infant, Newborn
Male
Membrane Glycoproteins / genetics*
Middle Aged
Polymorphism, Single Nucleotide / genetics*
Receptors, Cell Surface / genetics*
Staphylococcal Infections / genetics*
Staphylococcus aureus*
Toll-Like Receptor 2
Toll-Like Receptors

Substances

Membrane Glycoproteins
Receptors, Cell Surface
TLR2 protein, human
Toll-Like Receptor 2
Toll-Like Receptors