Translation of varicella-zoster virus genes during human ganglionic latency

Virus Genes. 2004 Dec;29(3):317-9. doi: 10.1007/s11262-004-7434-z.

Abstract

Immunohistochemical analysis of fixed tissue sections of human trigeminal ganglia (TG) and dorsal root ganglia (DRG) revealed the neuronal expression of proteins encoded by Varicella-zoster virus (VZV) genes 21, 29, 62 and 63. These proteins were detected mainly in the neuronal cytoplasm, are likely to be present in low abundance during VZV latency, and mirror the profile of VZV gene transcription.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cytoplasm / virology
  • Ganglia, Spinal / virology*
  • Genes, Viral*
  • Herpesvirus 3, Human / genetics
  • Herpesvirus 3, Human / physiology*
  • Humans
  • Immunohistochemistry
  • Neurons / virology
  • Protein Biosynthesis*
  • Trigeminal Ganglion / virology*
  • Viral Proteins / analysis
  • Viral Proteins / genetics
  • Virus Latency / genetics*

Substances

  • Viral Proteins