Late-onset optic pathway tumors in children with neurofibromatosis 1

Neurology. 2004 Nov 23;63(10):1944-6. doi: 10.1212/01.wnl.0000144341.16830.01.

Abstract

Identification of new optic pathway tumors (OPTs) and progression of pre-existing OPTs in children with neurofibromatosis 1 (NF1) have been reported infrequently after age 6. The authors present eight children with NF1 (mean age 12.2 years) seen in three NF1 centers who had either late-onset (four of eight) or late-progressive (seven of eight) OPT. Continued monitoring of individuals with NF1 into adulthood for the development of OPTs and for progression of known OPTs is warranted.

Publication types

  • Multicenter Study
  • Review

MeSH terms

  • Adolescent
  • Adult
  • Age of Onset
  • Astrocytoma / diagnosis
  • Astrocytoma / epidemiology*
  • Astrocytoma / genetics
  • Astrocytoma / therapy
  • Case Management
  • Child
  • Child, Preschool
  • Combined Modality Therapy
  • Disease Progression
  • Humans
  • Hypothalamic Neoplasms / epidemiology
  • Hypothalamic Neoplasms / genetics
  • Neurofibromatosis 1 / diagnosis
  • Neurofibromatosis 1 / epidemiology*
  • Optic Nerve Glioma / diagnosis
  • Optic Nerve Glioma / epidemiology*
  • Optic Nerve Glioma / genetics
  • Optic Nerve Glioma / therapy
  • Optic Nerve Neoplasms / diagnosis
  • Optic Nerve Neoplasms / epidemiology*
  • Optic Nerve Neoplasms / genetics
  • Optic Nerve Neoplasms / therapy
  • Retrospective Studies