Abstract
The in vitro and in vivo antichlamydial activities of dexamethasone and beclomethasone alone and in combination with an antibiotic were tested. In vitro, dexamethasone and beclomethasone decreased the number of inclusion-forming units versus the control number (P < 0.001). The combination of glucocorticoids with azithromycin, telithromycin, or levofloxacin was more active than antibiotics used alone (P < 0.001). The combination, tested in a murine Chlamydophila pneumoniae infection model, produced similar results.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Anti-Bacterial Agents / pharmacology*
-
Anti-Bacterial Agents / therapeutic use*
-
Anti-Inflammatory Agents / pharmacology
-
Anti-Inflammatory Agents / therapeutic use
-
Azithromycin / pharmacology
-
Azithromycin / therapeutic use
-
Cell Line
-
Chlamydophila Infections / drug therapy*
-
Chlamydophila Infections / microbiology
-
Chlamydophila pneumoniae / drug effects*
-
Dexamethasone / pharmacology
-
Dexamethasone / therapeutic use
-
Drug Synergism
-
Glucocorticoids / pharmacology*
-
Glucocorticoids / therapeutic use*
-
Humans
-
Ketolides / pharmacology
-
Ketolides / therapeutic use
-
Levofloxacin
-
Mice
-
Mice, Inbred BALB C
-
Microbial Sensitivity Tests
-
Ofloxacin / pharmacology
-
Ofloxacin / therapeutic use
Substances
-
Anti-Bacterial Agents
-
Anti-Inflammatory Agents
-
Glucocorticoids
-
Ketolides
-
Levofloxacin
-
Dexamethasone
-
Azithromycin
-
Ofloxacin
-
telithromycin