Abstract
We performed in vitro antifungal checkerboard testing on 12 Aspergillus fumigatus clinical isolates (6 transplant recipients and 6 nontransplant patients) with three antifungal agents (amphotericin B, voriconazole, and caspofungin) and three immunosuppressants (FK506, cyclosporine, and rapamycin). We were not able to detect a difference in calcineurin inhibitor antifungal activity against isolates from transplant recipients and nontransplant patients.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amphotericin B / pharmacology
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Antifungal Agents / pharmacology*
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Aspergillosis / drug therapy*
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Aspergillus fumigatus / drug effects*
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Calcineurin Inhibitors
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Caspofungin
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Cyclosporine / pharmacology
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Echinocandins
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Humans
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Immunosuppressive Agents / pharmacology*
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Lipopeptides
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Organ Transplantation*
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Peptides, Cyclic / pharmacology
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Pyrimidines / pharmacology
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Tacrolimus / pharmacology
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Triazoles / pharmacology
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Voriconazole
Substances
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Antifungal Agents
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Calcineurin Inhibitors
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Echinocandins
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Immunosuppressive Agents
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Lipopeptides
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Peptides, Cyclic
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Pyrimidines
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Triazoles
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Amphotericin B
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Cyclosporine
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Caspofungin
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Voriconazole
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Tacrolimus