Successful treatment of pure red cell aplasia associated with systemic lupus erythematosus with oral danazol and steroid

Alice Y K Chan; Edmund K Li; L S Tam; Gregory Cheng; Paul C L Choi

doi:10.1007/s00296-004-0521-6

Successful treatment of pure red cell aplasia associated with systemic lupus erythematosus with oral danazol and steroid

Rheumatol Int. 2005 Jun;25(5):388-90. doi: 10.1007/s00296-004-0521-6. Epub 2004 Nov 25.

Authors

Alice Y K Chan¹, Edmund K Li, L S Tam, Gregory Cheng, Paul C L Choi

Affiliation

¹ Rheumatology Unit, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong. [email protected]

PMID: 15565448
DOI: 10.1007/s00296-004-0521-6

Abstract

We describe a middle-aged Chinese systemic lupus erythematosus (SLE) patient developing steroid refractory and transfusion dependent red cell aplasia. Oral danazol 200 mg twice per day was started together with low-dose prednisolone therapy. There was no further recurrence of anemia 1 month after this combined therapy.

Publication types

Case Reports

MeSH terms

Administration, Oral
Danazol / therapeutic use*
Dose-Response Relationship, Drug
Drug Therapy, Combination
Estrogen Antagonists / therapeutic use*
Female
Glucocorticoids / therapeutic use*
Humans
Lupus Erythematosus, Systemic / complications
Lupus Erythematosus, Systemic / drug therapy*
Middle Aged
Prednisolone / therapeutic use*
Red-Cell Aplasia, Pure / complications
Red-Cell Aplasia, Pure / drug therapy*
Treatment Outcome

Substances

Estrogen Antagonists
Glucocorticoids
Prednisolone
Danazol