Undetectable plasma HIV-1 RNA with strong gag-pol specific interferon-gamma ELISPOT response in an HIV-1 clade A/E-infected child untreated with antiretroviral therapy

Jintanat Ananworanich; Chitsanu Pancharoen; Sunee Sirivichayakul; Supranee Buranapraditkun; Wichitra Apateerapong; Sasiwimol Ubolyam; Kiat Ruxrungtham

Undetectable plasma HIV-1 RNA with strong gag-pol specific interferon-gamma ELISPOT response in an HIV-1 clade A/E-infected child untreated with antiretroviral therapy

Asian Pac J Allergy Immunol. 2004 Jun-Sep;22(2-3):165-9.

Authors

Jintanat Ananworanich¹, Chitsanu Pancharoen, Sunee Sirivichayakul, Supranee Buranapraditkun, Wichitra Apateerapong, Sasiwimol Ubolyam, Kiat Ruxrungtham

Affiliation

¹ The HIV Netherlands Australia Thailand Research Collaboration and the Thai Red Cross AIDS Research Center, Thailand.

PMID: 15565954

Abstract

We report a 7-year HIV-1 clade A/E-infected child untreated with antiretroviral therapy who had positive HIV antibody testing but undetectable plasma HIV-1 RNA by Roche Amplicor version 1.5 and bDNA version 3.0. DNA PCR was positive by methods using gag/pol primers but not env/pol primers. The patient had strong HIV-1-specific cytotoxic T lymphocyte responses, which likely contributed to her low viral burden and undetectable plasma HIV-1 RNA.

Publication types

Case Reports

MeSH terms

Anti-Retroviral Agents*
Blotting, Western
Child
DNA Primers
DNA, Viral / blood
Enzyme-Linked Immunosorbent Assay
Female
Fusion Proteins, gag-pol / blood
Fusion Proteins, gag-pol / genetics*
HIV Infections / blood*
HIV Infections / diagnosis*
HIV Infections / immunology
HIV-1 / genetics*
HIV-1 / isolation & purification
Humans
Interferon-gamma / blood
Interferon-gamma / immunology
Polymerase Chain Reaction
RNA, Viral / blood*
Viral Load

Substances

Anti-Retroviral Agents
DNA Primers
DNA, Viral
Fusion Proteins, gag-pol
RNA, Viral
Interferon-gamma