Abstract
Data from 20 highly drug-experienced HIV-infected patients receiving tenofovir plus didanosine as part of a salvage regimen were analysed. At baseline, all but one patient harboured a virus bearing at least one nucleoside excision mutation (NEM); in 13 cases (65%) three or more NEM were detectable. After a median of 26 weeks of treatment, two patients (10%) selected the 65R mutation. These results support the hypothesis that NEM hinder the selection of this mutation.
MeSH terms
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Adenine / analogs & derivatives*
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Adenine / therapeutic use*
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Anti-HIV Agents / therapeutic use*
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Antiretroviral Therapy, Highly Active
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DNA, Viral / analysis
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Databases, Genetic
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Didanosine / therapeutic use*
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Drug Resistance, Multiple, Viral
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Gene Deletion
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Genotype
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HIV Infections / drug therapy*
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HIV Infections / virology
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HIV-1 / genetics*
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Humans
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Mutation
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Organophosphonates / therapeutic use*
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Tenofovir
Substances
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Anti-HIV Agents
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DNA, Viral
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Organophosphonates
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Tenofovir
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Adenine
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Didanosine