Drug susceptibility of Mycobacterium tuberculosis in HIV-infected and -uninfected Ethiopians and its impact on outcome after 24 months of follow-up

Int J Tuberc Lung Dis. 2004 Nov;8(11):1388-91.

Abstract

From a prospective cohort study on tuberculosis/human immunodeficiency virus (TB/HIV) interaction in Addis Ababa, Ethiopia, drug susceptibility results were available for 94 TB patients (46% HIV-infected). Resistance to one or more drug(s) was detected in 21 (22.3%) and multidrug resistance in five (5.3%) patients. Occurrence of resistance was not related to HIV status or outcome after 24 months of follow-up. However, among HIV-infected TB patients who died during follow-up, survival time in those with a resistant Mycobacterium tuberculosis strain was significantly shorter compared to those with a sensitive strain (6 vs. 13 months). Early detection of drug resistance and timely treatment change can therefore have a positive impact on survival in HIV-infected TB patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antitubercular Agents / therapeutic use*
  • Case-Control Studies
  • Drug Resistance, Bacterial
  • Ethiopia
  • Female
  • Follow-Up Studies
  • HIV Infections / complications*
  • HIV Infections / mortality
  • Humans
  • Male
  • Mycobacterium tuberculosis / drug effects*
  • Prospective Studies
  • Time Factors
  • Treatment Outcome
  • Tuberculosis, Pulmonary / drug therapy*
  • Tuberculosis, Pulmonary / mortality
  • Tuberculosis, Pulmonary / virology
  • Young Adult

Substances

  • Antitubercular Agents