Optimization of pyrrolidinone based HIV protease inhibitors

Bioorg Med Chem Lett. 2005 Jan 3;15(1):81-4. doi: 10.1016/j.bmcl.2004.10.029.

Authors

Ronald G Sherrill¹, C Webster Andrews, William J Bock, Ronda G Davis-Ward, Eric S Furfine, Richard J Hazen, Randy D Rutkowske, Andrew Spaltenstein, Lois L Wright

Affiliation

¹ GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA. [email protected]

PMID: 15582415
DOI: 10.1016/j.bmcl.2004.10.029

Abstract

Optimization of P1-substituted pyrrolidinone based HIV protease inhibitors has yielded analogs with very potent antiviral activity.

MeSH terms

HIV Protease Inhibitors / chemistry
HIV Protease Inhibitors / pharmacology*
Models, Molecular
Pyrrolidinones / chemistry
Pyrrolidinones / pharmacology*

Substances

HIV Protease Inhibitors
Pyrrolidinones